ZNF146 Belongs to the krueppel C2H2-type zinc-finger protein family. Liver, skeletal and heart muscle, mammary cells. Very low levels in brain, lung, placenta and kidney. Strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. Overexpressed in 80% of colorectal cancers. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding
Chromosomal Location of Human Ortholog: 19q13.12
Cellular Component:  cytosol; nucleolus; nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; heparin binding; zinc ion binding
Biological Process:  regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
Reference #:  Q15072 (UniProtKB)
Alt. Names/Synonyms: MGC125660; MGC125661; Only zinc finger protein; OZF; Zinc finger protein 146; Zinc finger protein OZF; ZNF146
Gene Symbols: ZNF146
Molecular weight: 33,308 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
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ZNF146

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein