JARID2 Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 13 A5|13 21.66 cM
Cellular Component:  histone methyltransferase complex; mitochondrion; nucleus
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone demethylase activity; protein binding; RNA polymerase II regulatory region sequence-specific DNA binding; transcription factor binding
Biological Process:  cell differentiation; cellular response to leukemia inhibitory factor; chromatin organization; chromatin remodeling; liver development; multicellular organism development; negative regulation of cardiac muscle cell proliferation; negative regulation of cardiac muscle hypertrophy; negative regulation of cell proliferation; negative regulation of histone methylation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of histone H3-K9 methylation; regulation of cell proliferation; spleen development; stem cell differentiation; thymus development
Reference #:  Q62315 (UniProtKB)
Alt. Names/Synonyms: AI317256; AU045941; C79929; C79931; JARD2; Jarid2; Jmj; jumo; jumonji; jumonji, AT rich interactive domain 2; Jumonji/ARID domain-containing protein 2; Protein Jumonji
Gene Symbols: Jarid2
Molecular weight: 137,445 Da
Basal Isoelectric point: 9.49  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene