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ATF-2
Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type. Belongs to the bZIP family. ATF subfamily. Ubiquitously expressed, with more abundant expression in the brain. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor |
| Chromosomal Location of human Ortholog: 2q31.1 |
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Cellular Component:
chromatin; cytoplasm; H4 histone acetyltransferase complex; mitochondrial outer membrane; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex; site of double-strand break
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Molecular Function:
cAMP response element binding; cAMP response element binding protein binding; cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; histone acetyltransferase activity; histone H2B acetyltransferase activity; histone H4 acetyltransferase activity; identical protein binding; leucine zipper domain binding; metal ion binding; promoter-specific chromatin binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific double-stranded DNA binding
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Biological Process:
abducens nucleus development; adipose tissue development; apoptotic process involved in development; BMP signaling pathway; brainstem development; cellular lipid metabolic process; cellular response to anisomycin; cellular response to leucine starvation; cellular response to oxidative stress; cellular response to virus; detection of cell density; DNA damage response; facial nucleus development; gene expression; growth plate cartilage chondrocyte differentiation; growth plate cartilage chondrocyte proliferation; hematopoietic progenitor cell differentiation; hepatocyte apoptotic process; hypoglossal nucleus development; in utero embryonic development; intrinsic apoptotic signaling pathway in response to hypoxia; JNK cascade; liver development; mitotic intra-S DNA damage checkpoint signaling; motor neuron apoptotic process; mRNA transcription by RNA polymerase II; negative regulation of angiogenesis; negative regulation of transcription by RNA polymerase II; neurofilament cytoskeleton organization; NK T cell differentiation; outflow tract morphogenesis; p38MAPK cascade; peptidyl-threonine phosphorylation; positive regulation of cardiac muscle myoblast proliferation; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression; positive regulation of mitochondrial membrane permeability involved in apoptotic process; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus; positive regulation of transforming growth factor beta2 production; protein import into nucleus; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to organic cyclic compound; response to osmotic stress; transcription initiation-coupled chromatin remodeling; vacuole organization; white fat cell differentiation
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Reference #:
P15336
(UniProtKB)
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Alt. Names/Synonyms: Activating transcription factor 2; activating transcription factor 2 splice variant ATF2-var2; ATF-2; ATF2; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE-BP1; CREB-2; CREB2; CREBP1; Cyclic AMP-dependent transcription factor ATF-2; Cyclic AMP-responsive element-binding protein 2; HB16; histone acetyltransferase ATF2; MGC111558; TREB7
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Gene Symbols: ATF2
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Molecular weight:
54,537 Da
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Basal Isoelectric point:
7.75
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Regulation of P38 MAPKs
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SAPK/JNK Signaling Cascades
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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