OAS1 Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Transferase
Chromosomal Location of Human Ortholog: 12q24.13
Cellular Component:  cytosol; endoplasmic reticulum; extracellular region; mitochondrion
Molecular Function:  2'-5'-oligoadenylate synthetase activity; ATP binding; double-stranded RNA binding; metal ion binding; protein binding
Biological Process:  defense response to virus; glucose homeostasis; glucose metabolic process; interferon-gamma-mediated signaling pathway; negative regulation of viral genome replication; response to virus; type I interferon signaling pathway
Disease: Diabetes Mellitus, Insulin-dependent
Reference #:  P00973 (UniProtKB)
Alt. Names/Synonyms: (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthetase 1; 2',5'-oligo A synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1 p48 isoform; 2'-5' oligoadenylate synthetase 1 p52 isoform; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthetase 1; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthetase 1; E18/E16; IFI-4; OAS1; OIAS; OIASI; p46/p42 OAS
Gene Symbols: OAS1
Molecular weight: 46,029 Da
Basal Isoelectric point: 8.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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