HMGCS1 This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the HMG-CoA synthase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC; Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase
Chromosomal Location of Human Ortholog: 5p12
Cellular Component:  cytoplasm; cytosol
Molecular Function:  drug binding; hydroxymethylglutaryl-CoA synthase activity; isomerase activity; organic acid binding; protein homodimerization activity
Biological Process:  brain development; cellular response to cholesterol; cellular response to follicle-stimulating hormone stimulus; cellular response to low-density lipoprotein particle stimulus; cholesterol biosynthetic process; lipid metabolic process; liver development; male gonad development; regulation of cholesterol biosynthetic process; regulation of lipid metabolic process; response to drug; response to low light intensity stimulus; response to purine-containing compound; response to tellurium ion; response to vitamin E
Reference #:  Q01581 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase; 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMCS1; HMG-CoA synthase; HMGCS; HMGCS1; Hydroxymethylglutaryl-CoA synthase, cytoplasmic; MGC90332
Gene Symbols: HMGCS1
Molecular weight: 57,294 Da
Basal Isoelectric point: 5.22  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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