MCMBP Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion. Belongs to the MCMBP family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 10q26.11
Cellular Component:  cytosol; nucleoplasm; nucleus; plasma membrane
Molecular Function:  chromatin binding; protein binding
Biological Process:  cell division; DNA-dependent DNA replication; sister chromatid cohesion
Reference #:  Q9BTE3 (UniProtKB)
Alt. Names/Synonyms: C10orf119; chromosome 10 open reading frame 119; CJ119; FLJ13081; FLJ36756; MCM-binding protein; MCM-BP; MCMBP; Mini-chromosome maintenance complex-binding protein; minichromosome maintenance complex binding protein; minichromosome maintenance complex-binding protein; UPF0557 protein C10orf119
Gene Symbols: MCMBP
Molecular weight: 72,980 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Select Structure to View Below

MCMBP

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene