ARPP-21 Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 3p22.3
Cellular Component:  cytoplasm
Molecular Function:  calmodulin binding; nucleic acid binding
Biological Process:  cellular response to heat
Reference #:  Q9UBL0 (UniProtKB)
Alt. Names/Synonyms: AC104308.1; ARP21; ARPP-21; ARPP21; cAMP-regulated phosphoprotein 21; cyclic AMP-regulated phosphoprotein, 21 kD; FLJ32997; RCS; TARPP; thymocyte cAMP-regulated phosphoprotein
Gene Symbols: ARPP21
Molecular weight: 89,196 Da
Basal Isoelectric point: 6.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein