HBEGF Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18 B2|18 19.46 cM
Cellular Component:  cell surface; extracellular region; extracellular space; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane
Molecular Function:  epidermal growth factor receptor binding; growth factor activity; heparin binding
Biological Process:  angiogenesis; blastocyst growth; cell chemotaxis; cell migration; epidermal growth factor receptor signaling pathway; negative regulation of elastin biosynthetic process; positive regulation of cell growth; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of keratinocyte migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell proliferation; positive regulation of wound healing; regulation of heart contraction; wound healing, spreading of epidermal cells
Reference #:  Q06186 (UniProtKB)
Alt. Names/Synonyms: AW047313; diphtheria toxin receptor; Dtr; Dts; HB-EGF; HBEGF; Hegfl; heparin binding epidermal growth factor-like growth factor; Heparin-binding EGF-like growth factor; MGC107656; Proheparin-binding EGF-like growth factor
Gene Symbols: Hbegf
Molecular weight: 22,808 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene