HBEGF Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. Note: This description may include information from UniProtKB.
Protein type: Cell surface; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5q31.3
Cellular Component:  cell surface; clathrin-coated endocytic vesicle membrane; clathrin-coated vesicle membrane; endocytic vesicle membrane; extracellular region; extracellular space; integral component of plasma membrane; plasma membrane
Molecular Function:  growth factor activity; heparin binding
Biological Process:  cell chemotaxis; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; MAPK cascade; membrane organization; muscle organ development; negative regulation of elastin biosynthetic process; negative regulation of epidermal growth factor receptor signaling pathway; positive regulation of cell growth; positive regulation of cell migration; positive regulation of keratinocyte migration; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell proliferation; positive regulation of wound healing; regulation of cell motility; regulation of heart contraction; regulation of signaling receptor activity; signal transduction; wound healing, spreading of epidermal cells
Reference #:  Q99075 (UniProtKB)
Alt. Names/Synonyms: Diphtheria toxin receptor; diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); DT-R; DTR; DTS; DTSF; HB-EGF; HBEGF; HEGFL; heparin binding EGF like growth factor; Heparin-binding EGF-like growth factor; heparin-binding epidermal growth factor; Proheparin-binding EGF-like growth factor
Gene Symbols: HBEGF
Molecular weight: 23,067 Da
Basal Isoelectric point: 9.47  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling
Select Structure to View Below

HBEGF

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene