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RUVBL1
a transcriptional-regulatory protein with ATP-dependent DNA helicase (3' to 5') activity that is stimulated by single-stranded DNA. Hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Belongs to the RuvB family. Ubiquitously expressed with high expression in heart, skeletal muscle and testis. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.6.4.12; Helicase; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 6|6 D1 |
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Cellular Component:
cytoplasm; cytoskeleton; cytosol; Ino80 complex; membrane; MLL1 complex; NuA4 histone acetyltransferase complex; nuclear matrix; nucleoplasm; nucleosome; nucleus; protein folding chaperone complex; protein-containing complex; R2TP complex; ribonucleoprotein complex; RPAP3/R2TP/prefoldin-like complex; Swr1 complex
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Molecular Function:
3'-5' DNA helicase activity; ADP binding; ATP binding; ATP hydrolysis activity; ATP-dependent activity, acting on DNA; ATPase binding; DNA helicase activity; helicase activity; hydrolase activity; nucleotide binding; protein binding; TBP-class protein binding; TFIID-class transcription factor complex binding; transcription coactivator activity
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Biological Process:
box C/D snoRNP assembly; cell cycle; cell division; chromatin organization; chromatin remodeling; DNA damage response; DNA recombination; DNA repair; histone acetylation; histone H2A acetylation; histone H4 acetylation; positive regulation of canonical Wnt signaling pathway; positive regulation of DNA repair; positive regulation of DNA-templated transcription; positive regulation of double-strand break repair via homologous recombination; positive regulation of telomere maintenance in response to DNA damage; regulation of apoptotic process; regulation of cell cycle; regulation of chromosome organization; regulation of DNA repair; regulation of DNA replication; regulation of DNA strand elongation; regulation of DNA-templated transcription; regulation of double-strand break repair; regulation of embryonic development; regulation of transcription by RNA polymerase II; telomere maintenance
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Reference #:
P60122
(UniProtKB)
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Alt. Names/Synonyms: 2510009G06Rik; 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; DNA helicase p50; OTTMUSP00000028402; Pon; Pontin 52; Pontin52; RuvB-like 1; RuvB-like protein 1; RUVB1; Ruvbl1; Tip; Tip49; TIP49a
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Gene Symbols: Ruvbl1
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Molecular weight:
50,214 Da
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Basal Isoelectric point:
6.02
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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