RUVBL1 a transcriptional-regulatory protein with ATP-dependent DNA helicase (3' to 5') activity that is stimulated by single-stranded DNA. Hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome. Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation. May be able to bind plasminogen at cell surface and enhance plasminogen activation. Belongs to the RuvB family. Ubiquitously expressed with high expression in heart, skeletal muscle and testis. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Helicase; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component:  cytosol; Ino80 complex; membrane; microtubule organizing center; MLL1 complex; NuA4 histone acetyltransferase complex; nuclear matrix; nucleoplasm; nucleus; R2TP complex; ribonucleoprotein complex; Swr1 complex
Molecular Function:  ADP binding; ATP binding; ATP-dependent 5'-3' DNA helicase activity; ATPase activity; ATPase binding; DNA helicase activity; protein binding; TBP-class protein binding; TFIID-class transcription factor complex binding; transcription coactivator activity
Biological Process:  beta-catenin-TCF complex assembly; cell cycle; cell division; CENP-A containing nucleosome assembly; DNA duplex unwinding; DNA recombination; DNA repair; histone H2A acetylation; histone H4 acetylation; positive regulation of canonical Wnt signaling pathway; positive regulation of nucleic acid-templated transcription; protein deubiquitination; regulation of growth; spermatogenesis
Reference #:  Q9Y265 (UniProtKB)
Alt. Names/Synonyms: 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; 54 kDa erythrocyte cytosolic protein; ECP-54; ECP54; INO80 complex subunit H; INO80H; NMP 238; NMP238; Nuclear matrix protein 238; PONTIN; Pontin 52; Pontin52; RuvB (E coli homolog)-like 1; RuvB-like 1; RuvB-like 1 (E. coli); RUVB1; RUVBL1; RVB1; TAP54-alpha; TATA binding protein interacting protein 49 kDa; TIH1; TIP49; TIP49A; TIP60-associated protein 54-alpha
Gene Symbols: RUVBL1
Molecular weight: 50,228 Da
Basal Isoelectric point: 6.02  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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