AR a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor; Transcription factor
Chromosomal Location of Human Ortholog: Xq12
Cellular Component:  cytoplasm; cytosol; nuclear chromatin; nuclear speck; nucleoplasm; nucleus; plasma membrane; protein-containing complex
Molecular Function:  androgen binding; ATPase binding; beta-catenin binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; nuclear receptor activity; POU domain binding; protein binding; protein dimerization activity; RNA polymerase II basal transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II transcription factor binding; signaling receptor binding; steroid binding; steroid hormone receptor activity; transcription factor binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process:  activation of prostate induction by androgen receptor signaling pathway; androgen receptor signaling pathway; animal organ formation; cell proliferation; cell-cell signaling; cellular response to steroid hormone stimulus; cellular response to testosterone stimulus; epithelial cell differentiation involved in prostate gland development; epithelial cell morphogenesis; in utero embryonic development; intracellular receptor signaling pathway; lateral sprouting involved in mammary gland duct morphogenesis; Leydig cell differentiation; male genitalia morphogenesis; male somatic sex determination; mammary gland alveolus development; morphogenesis of an epithelial fold; multicellular organism growth; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of integrin biosynthetic process; negative regulation of transcription by RNA polymerase II; positive regulation of cell differentiation; positive regulation of cell proliferation; positive regulation of epithelial cell proliferation involved in prostate gland development; positive regulation of gene expression; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of integrin biosynthetic process; positive regulation of intracellular estrogen receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase III; positive regulation of transcription, DNA-templated; prostate gland development; prostate gland epithelium morphogenesis; prostate gland growth; protein complex oligomerization; protein deubiquitination; regulation of developmental growth; regulation of protein localization to plasma membrane; regulation of systemic arterial blood pressure; seminiferous tubule development; sex differentiation; signal transduction; single fertilization; spermatogenesis; tertiary branching involved in mammary gland duct morphogenesis; transcription initiation from RNA polymerase II promoter; transcription, DNA-templated
Disease: Androgen Insensitivity Syndrome; Androgen Insensitivity, Partial; Hypospadias 1, X-linked; Prostate Cancer; Spinal And Bulbar Muscular Atrophy, X-linked 1
Reference #:  P10275 (UniProtKB)
Alt. Names/Synonyms: AIS; ANDR; Androgen receptor; AR; DHTR; Dihydrotestosterone receptor; HUMARA; HYSP1; KD; NR3C4; Nuclear receptor subfamily 3 group C member 4; SBMA; SMAX1; TFM
Gene Symbols: AR
Molecular weight: 99,188 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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