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ADNP
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. Widely expressed. Strong expression in heart, skeletal muscle, kidney and placenta. In brain, expression is stronger in the cerebellum and cortex regions. No expression detected in the colon. Strong increase of expression in colon and breast cancer tissues. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; C2H2-type zinc finger protein; DNA-binding |
| Chromosomal Location of human Ortholog: 20q13.13 |
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Cellular Component:
axon; chromatin; dendrite; extracellular space; neuronal cell body; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
beta-catenin binding; beta-tubulin binding; chromatin binding; copper ion binding; DNA-binding transcription factor activity, RNA polymerase II-specific; peptide binding; protein binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding
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Biological Process:
activation of protein kinase activity; cellular response to extracellular stimulus; cGMP-mediated signaling; estrous cycle; intracellular nitric oxide homeostasis; negative regulation of gene expression; negative regulation of neuron apoptotic process; negative regulation of protein binding; negative regulation of protein phosphorylation; negative regulation of synaptic transmission; neuron apoptotic process; neuron differentiation; positive regulation of axon extension; positive regulation of canonical Wnt signaling pathway; positive regulation of neuron projection development; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of synapse assembly; regulation of gene expression; regulation of protein ADP-ribosylation; regulation of transcription by RNA polymerase II; response to carbohydrate; response to inorganic substance; short-term memory
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Disease: Mental Retardation, Autosomal Dominant 28
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Reference #:
Q9H2P0
(UniProtKB)
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Alt. Names/Synonyms: activity dependent neuroprotector homeobox; Activity-dependent neuroprotective protein; activity-dependent neuroprotector; activity-dependent neuroprotector homeobox; Activity-dependent neuroprotector homeobox protein; ADNP; ADNP homeobox 1; ADNP1; HVDAS; KIAA0784; MRD28
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Gene Symbols: ADNP
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Molecular weight:
123,563 Da
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Basal Isoelectric point:
6.97
Predict pI for various phosphorylation states
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