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DZIP3
E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ligase; RNA-binding; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 16|16 B5 |
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Cellular Component:
cytoplasm
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Molecular Function:
metal ion binding; phosphatase binding; polyubiquitin modification-dependent protein binding; RNA binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
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Biological Process:
protein polyubiquitination
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Reference #:
Q7TPV2
(UniProtKB)
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Alt. Names/Synonyms: 2310047C04Rik; 2A-HU; 2A-HUB; 6430549P11Rik; A230104G20; DAZ interacting protein 3, zinc finger; DAZ-interacting protein 3 homolog; Dzip3; E3 ubiquitin-protein ligase DZIP3; Kiaa0675; RING-type E3 ubiquitin transferase DZIP3
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Gene Symbols: Dzip3
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Molecular weight:
138,021 Da
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Basal Isoelectric point:
5.23
Predict pI for various phosphorylation states
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