DZIP3 E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA. Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 6.3.2.-; EC; Ligase; RNA-binding; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of mouse Ortholog: 16|16 B5
Cellular Component:  cytoplasm
Molecular Function:  metal ion binding; phosphatase binding; polyubiquitin modification-dependent protein binding; RNA binding; transferase activity; ubiquitin protein ligase activity; ubiquitin-protein transferase activity
Biological Process:  protein polyubiquitination
Reference #:  Q7TPV2 (UniProtKB)
Alt. Names/Synonyms: 2310047C04Rik; 2A-HU; 2A-HUB; 6430549P11Rik; A230104G20; DAZ interacting protein 3, zinc finger; DAZ-interacting protein 3 homolog; Dzip3; E3 ubiquitin-protein ligase DZIP3; Kiaa0675; RING-type E3 ubiquitin transferase DZIP3
Gene Symbols: Dzip3
Molecular weight: 138,021 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene