HSD17B4 Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Present in many tissues with highest concentrations in liver, heart, prostate and testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; EC 1.1.1.n12; EC; EC; Lipid Metabolism - primary bile acid biosynthesis; Lyase; Mitochondrial; Oxidoreductase
Chromosomal Location of mouse Ortholog: 18|18 D1
Cellular Component:  peroxisome
Molecular Function:  17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydratase activity; 3-hydroxyacyl-CoA dehydrogenase activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; estradiol 17-beta-dehydrogenase activity; isomerase activity; long-chain-enoyl-CoA hydratase activity; lyase activity; oxidoreductase activity; protein homodimerization activity; signaling receptor binding
Biological Process:  androgen metabolic process; estrogen metabolic process; fatty acid beta-oxidation; fatty acid metabolic process; lipid metabolic process; medium-chain fatty-acyl-CoA metabolic process; oxidation-reduction process; Sertoli cell development; very long-chain fatty acid metabolic process; very long-chain fatty-acyl-CoA metabolic process
Reference #:  P51660 (UniProtKB)
Alt. Names/Synonyms: (3R)-hydroxyacyl-CoA dehydrogenase; 17-beta-HSD; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 17[b]-HS; 17[b]-HSD; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 3-hydroxyacyl-CoA dehydrogenase; AW208803; D-bifunctional protein; DBP; DHB4; Edh17b4; Enoyl-CoA hydratase 2; Hsd17b4; hydroxysteroid (17-beta) dehydrogenase 4; MFE-2; MFP; Mfp-; Mfp-2; MFP2; MPF-2; multifunctional protein 2; OTTMUSP00000023277; perMFE; perMFE-2; Peroxisomal multifunctional enzyme type 2
Gene Symbols: Hsd17b4
Molecular weight: 79,482 Da
Basal Isoelectric point: 8.76  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene