HSD17B4 Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Present in many tissues with highest concentrations in liver, heart, prostate and testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; EC 1.1.1.n12; EC; EC; Lipid Metabolism - primary bile acid biosynthesis; Lyase; Mitochondrial; Oxidoreductase
Chromosomal Location of human Ortholog: 5q23.1
Cellular Component:  cytosol; peroxisomal matrix; peroxisome
Molecular Function:  (3R)-hydroxyacyl-CoA dehydrogenase (NAD) activity; 17-beta-hydroxysteroid dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydratase activity; 3-hydroxyacyl-CoA dehydrogenase activity; 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity; enoyl-CoA hydratase activity; estradiol 17-beta-dehydrogenase [NAD(P)] activity; isomerase activity; protein homodimerization activity
Biological Process:  androgen metabolic process; estrogen metabolic process; fatty acid beta-oxidation; medium-chain fatty-acyl-CoA metabolic process; Sertoli cell development; very long-chain fatty acid metabolic process; very long-chain fatty-acyl-CoA metabolic process
Disease: D-bifunctional Protein Deficiency; Perrault Syndrome 1
Reference #:  P51659 (UniProtKB)
Alt. Names/Synonyms: (3R)-hydroxyacyl-CoA dehydrogenase; 17-beta-HSD 4; 17-beta-HSD IV; 17-beta-hydroxysteroid dehydrogenase 4; 17beta-estradiol dehydrogenase type IV; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase; 3-hydroxyacyl-CoA dehydrogenase; beta-hydroxyacyl dehydrogenase; beta-keto-reductase; D-3-hydroxyacyl-CoA dehydratase; D-bifunctional protein; D-bifunctional protein, peroxisomal; DBP; DHB4; EDH17B4; Enoyl-CoA hydratase 2; epididymis secretory sperm binding protein; HSD17B4; hydroxysteroid (17-beta) dehydrogenase 4; hydroxysteroid 17-beta dehydrogenase 4; hydroxysteroid dehydrogenase 4; MFE-2; MFP-2; MPF-2; Multifunctional protein 2; Peroxisomal multifunctional enzyme type 2; peroxisomal multifunctional protein 2; PRLTS1; SDR8C1; Short chain dehydrogenase/reductase family 8C member 1; short chain dehydrogenase/reductase family 8C, member 1
Gene Symbols: HSD17B4
Molecular weight: 79,686 Da
Basal Isoelectric point: 8.96  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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