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FOXO4
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Oncoprotein; Transcription factor |
| Chromosomal Location of human Ortholog: Xq13.1 |
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Cellular Component:
chromatin; cytoplasm; cytosol; nuclear speck; nucleoplasm; nucleus
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Molecular Function:
beta-catenin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; enzyme binding; identical protein binding; nucleic acid binding; promoter-specific chromatin binding; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
insulin receptor signaling pathway; mitotic G2 DNA damage checkpoint signaling; muscle organ development; negative regulation of angiogenesis; negative regulation of cell population proliferation; negative regulation of G0 to G1 transition; negative regulation of smooth muscle cell differentiation; positive regulation of smooth muscle cell migration; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; response to nutrient levels; response to oxidative stress; response to water-immersion restraint stress; stem cell differentiation
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Reference #:
P98177
(UniProtKB)
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Alt. Names/Synonyms: AFX; AFX1; Fork head domain transcription factor AFX1; forkhead box O4; Forkhead box protein O4; FOXO4; MGC120490; MLLT7; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
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Gene Symbols: FOXO4
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Molecular weight:
53,684 Da
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Basal Isoelectric point:
5.13
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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Insulin Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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