UBE2N The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Acts together with the E3 ligases, HLTF and SHPRH, in the 'Lys-63'-linked poly-ubiquitination of PCNA upon genotoxic stress, which is required for DNA repair. Appears to act together with E3 ligase RNF5 in the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Belongs to the ubiquitin-conjugating enzyme family. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC; Ligase; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 10|10 C2
Cellular Component:  cytoplasm; fibrillar center; nucleus; protein-containing complex; UBC13-MMS2 complex; UBC13-UEV1A complex; ubiquitin ligase complex
Molecular Function:  ATP binding; nucleotide binding; protein binding; transferase activity; ubiquitin binding; ubiquitin conjugating enzyme activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity
Biological Process:  cellular response to DNA damage stimulus; DNA double-strand break processing; DNA repair; double-strand break repair via homologous recombination; histone ubiquitination; positive regulation of DNA repair; positive regulation of histone modification; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of NF-kappaB transcription factor activity; positive regulation of ubiquitin-protein transferase activity; postreplication repair; protein K63-linked ubiquitination; protein ubiquitination; regulation of histone ubiquitination; T cell receptor signaling pathway; ubiquitin-dependent protein catabolic process
Reference #:  P61089 (UniProtKB)
Alt. Names/Synonyms: 1500026J17Rik; AL022654; BB101821; Bendless-like ubiquitin-conjugating enzyme; Blu; E2 ubiquitin-conjugating enzyme N; Ubc13; Ube2n; Ubiquitin carrier protein N; Ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N; Ubiquitin-protein ligase N
Gene Symbols: Ube2n
Molecular weight: 17,138 Da
Basal Isoelectric point: 6.13  Predict pI for various phosphorylation states
CST Pathways:  NF-kB Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene