CAPZA1 F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Belongs to the F-actin-capping protein alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3 F2.2|3 45.88 cM
Cellular Component:  actin cortical patch; brush border; cell-cell junction; cortical cytoskeleton; cytoplasm; cytoskeleton; F-actin capping protein complex; membrane; WASH complex
Molecular Function:  actin binding; actin filament binding; protein binding
Biological Process:  actin cytoskeleton organization; actin filament capping; barbed-end actin filament capping; cell junction assembly
Reference #:  P47753 (UniProtKB)
Alt. Names/Synonyms: Cappa1; capping protein (actin filament) muscle Z-line, alpha 1; capping protein alpha 1; CAPZ; CapZ alpha-1; Capza1; CAZ1; CAZA1; F-actin capping protein alpha-1 subunit; F-actin-capping protein subunit alpha-1; OTTMUSP00000025120
Gene Symbols: Capza1
Molecular weight: 32,940 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene