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CAPZA1
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. Belongs to the F-actin-capping protein alpha subunit family. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 1p13.2 |
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Cellular Component:
actin cytoskeleton; cytoskeleton; cytosol; extracellular region; F-actin capping protein complex; WASH complex
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Molecular Function:
actin binding; actin filament binding; protein binding
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Biological Process:
actin cytoskeleton organization; barbed-end actin filament capping; cell junction assembly; protein-containing complex assembly
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Reference #:
P52907
(UniProtKB)
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Alt. Names/Synonyms: Cap Z; CAPPA1; capping actin protein of muscle Z-line alpha subunit 1; capping actin protein of muscle Z-line subunit alpha 1; capping protein (actin filament) muscle Z-line, alpha 1; CAPZ; CapZ alpha-1; CAPZA1; CAZ1; CAZA1; F-actin-capping protein subunit alpha-1
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Gene Symbols: CAPZA1
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Molecular weight:
32,923 Da
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Basal Isoelectric point:
5.45
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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