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ADSL
Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. Ubiquitously expressed. Both isoforms are produced by all tissues. Isoform 2 is 10-fold less abundant than isoform 1. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - alanine, aspartate and glutamate; EC 4.3.2.2; Lyase; Nucleotide Metabolism - purine |
| Chromosomal Location of human Ortholog: 22q13.1 |
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Cellular Component:
cytosol; protein-containing complex
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Molecular Function:
(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity; identical protein binding; N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
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Biological Process:
'de novo' AMP biosynthetic process; 'de novo' IMP biosynthetic process; 'de novo' XMP biosynthetic process; aerobic respiration; AMP biosynthetic process; AMP salvage; GMP biosynthetic process; purine nucleotide biosynthetic process; response to hypoxia; response to muscle activity; response to nutrient; response to starvation
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Disease: Adenylosuccinase Deficiency
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Reference #:
P30566
(UniProtKB)
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Alt. Names/Synonyms: Adenylosuccinase; Adenylosuccinate lyase; ADSL; AMPS; ASase; ASL; PUR8
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Gene Symbols: ADSL
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Molecular weight:
54,889 Da
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Basal Isoelectric point:
6.68
Predict pI for various phosphorylation states
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