PRDX3 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q26.11
Cellular Component:  cytoplasm; cytosol; early endosome; mitochondrial matrix; mitochondrion; protein-containing complex
Molecular Function:  alkyl hydroperoxide reductase activity; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding; kinase binding; protein binding; protein C-terminus binding; protein kinase binding; thioredoxin peroxidase activity
Biological Process:  apoptotic process; cellular oxidant detoxification; cellular response to oxidative stress; cellular response to reactive oxygen species; hydrogen peroxide catabolic process; maternal placenta development; mitochondrion organization; myeloid cell differentiation; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of kinase activity; peptidyl-cysteine oxidation; positive regulation of cell proliferation; positive regulation of NF-kappaB transcription factor activity; regulation of mitochondrial membrane potential; response to hydrogen peroxide; response to lipopolysaccharide; response to oxidative stress
Reference #:  P30048 (UniProtKB)
Alt. Names/Synonyms: Antioxidant protein 1; AOP-1; AOP1; epididymis secretory sperm binding protein; HBC189; MER5; MGC104387; MGC24293; peroxiredoxin 3; Peroxiredoxin III; Peroxiredoxin-3; PRDX3; PRO1748; Protein MER5 homolog; Prx-III; SP-22; Thioredoxin-dependent peroxide reductase, mitochondrial; Thioredoxin-dependent peroxiredoxin 3
Gene Symbols: PRDX3
Molecular weight: 27,693 Da
Basal Isoelectric point: 7.68  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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