ZNF638 Transcription factor that binds to cytidine clusters in double-stranded DNA. Plays a key role in the silencing of unintegrated retroviral DNA: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. Mediates transcriptional repression of unintegrated viral DNA by specifically binding to the cytidine clusters of retroviral DNA and mediating the recruitment of chromatin silencers, such as the HUSH complex, SETDB1 and the histone deacetylases HDAC1 and HDAC4. Acts as an early regulator of adipogenesis by acting as a transcription cofactor of CEBPs (CEBPA, CEBPD and/or CEBPG), controlling the expression of PPARG and probably of other proadipogenic genes, such as SREBF1. May also regulate alternative splicing of target genes during adipogenesis. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; RNA-binding
Chromosomal Location of mouse Ortholog: 6|6 C3
Cellular Component:  intracellular membrane-bounded organelle; nucleoplasm; nucleus
Molecular Function:  DNA binding; metal ion binding; mRNA binding; nucleic acid binding; RNA binding; zinc ion binding
Biological Process:  regulation of RNA splicing; RNA splicing
Reference #:  Q61464 (UniProtKB)
Alt. Names/Synonyms: AI323587; mNP220; Np2; Np220; Nuclear protein 220; Zfm; Zfml; Zfp638; Zinc finger matrin-like protein; Zinc finger protein 638; zinc finger, matrin-like; ZN638; Znf638
Gene Symbols: Zfp638
Molecular weight: 218,134 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
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ZNF638

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein