ZNF183 Required for pre-mRNA splicing as component of the spliceosome. E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins. Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains. Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents. Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: Xq24
Cellular Component:  nuclear speck; nucleus; U2-type precatalytic spliceosome
Molecular Function:  metal ion binding; protein binding; ubiquitin-protein transferase activity
Biological Process:  DNA repair; isopeptide cross-linking via N6-glycyl-L-lysine; mRNA splicing, via spliceosome; negative regulation of chemokine-mediated signaling pathway; protein ubiquitination
Disease: Trichothiodystrophy 5, Nonphotosensitive
Reference #:  O15541 (UniProtKB)
Alt. Names/Synonyms: Cwc24; Cwc24 homolog; E3 ubiquitin-protein ligase RNF113A; R113A; RING finger protein 113A; RNF113; RNF113A; TTD5; Zinc finger protein 183; zinc finger protein 183 (RING finger, C3HC4 type); ZNF183
Gene Symbols: RNF113A
Molecular weight: 38,787 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene