ANPA a transmembrane guanylyl cyclase enzyme with a tyrosine kinse domain. Receptor for natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction. Note: This description may include information from UniProtKB.
Protein type: EC; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc.
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component:  integral component of membrane; plasma membrane; receptor complex
Molecular Function:  ATP binding; G protein-coupled peptide receptor activity; GTP binding; guanylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; protein kinase activity; protein kinase binding
Biological Process:  body fluid secretion; cell surface receptor signaling pathway; cGMP biosynthetic process; cGMP-mediated signaling; dopamine metabolic process; G protein-coupled receptor signaling pathway; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of smooth muscle cell proliferation; positive regulation of cGMP-mediated signaling; positive regulation of renal sodium excretion; positive regulation of urine volume; protein phosphorylation; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of blood vessel diameter; regulation of cardiac conduction; regulation of vascular permeability
Reference #:  P16066 (UniProtKB)
Alt. Names/Synonyms: ANP-A; ANPa; ANPR-A; ANPRA; Atrial natriuretic peptide receptor 1; Atrial natriuretic peptide receptor type A; atrionatriuretic peptide receptor A; GC-A; Guanylate cyclase A; GUC2A; GUCY2A; natriuretic peptide A type receptor; natriuretic peptide receptor 1; natriuretic peptide receptor A; natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A); NPR-A; NPR1; NPRA; testicular tissue protein Li 20
Gene Symbols: NPR1
Molecular weight: 118,919 Da
Basal Isoelectric point: 6.19  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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