SRGAP2 RAC1 GTPase activating protein (GAP) that binds and deforms membranes, and regulates actin dynamics to regulate cell migration and differentiation. Plays an important role in different aspects of neuronal morphogenesis and migration mainly during development of the cerebral cortex. This includes the biogenesis of neurites, where it is required for both axons and dendrites outgrowth, and the maturation of the dendritic spines. Also stimulates the branching of the leading process and negatively regulates neuron radial migration in the cerebral cortex. Its interaction and inhibition by SRGAP2C reduces the rate of spine maturation, alters dendritic spine morphology and density and indirectly increases neuronal migration. It may have implications for cognition, learning and memory. In non-neuronal cells, it may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho; Mitochondrial; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  cell junction; cytosol; dendritic spine head; lamellipodium; nucleus; phagocytic vesicle; plasma membrane; postsynaptic density; postsynaptic membrane
Molecular Function:  GTPase activator activity; identical protein binding; protein binding; protein homodimerization activity; Rac GTPase binding
Biological Process:  actin filament severing; dendritic spine development; extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration; filopodium assembly; lamellipodium assembly involved in ameboidal cell migration; negative regulation of neuron migration; neuron projection morphogenesis; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction; substrate adhesion-dependent cell spreading
Reference #:  O75044 (UniProtKB)
Alt. Names/Synonyms: ARHGAP34; FNBP2; formin binding protein 2; Formin-binding protein 2; KIAA0456; Rho GTPase-activating protein 34; SLIT-ROBO GAP2; SLIT-ROBO Rho GTPase activating protein 2; SLIT-ROBO Rho GTPase-activating protein 2; SRGAP2; SRGAP2A; SRGAP3; SRGP2
Gene Symbols: SRGAP2
Molecular weight: 120,871 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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