PTP-SL Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of Human Ortholog: 12q15
Cellular Component:  cell junction; cytosol; integral component of membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  protein binding; protein kinase binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity
Biological Process:  ERBB2 signaling pathway; in utero embryonic development; negative regulation of epithelial cell migration; negative regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine dephosphorylation; protein dephosphorylation
Reference #:  Q15256 (UniProtKB)
Alt. Names/Synonyms: Ch-1 PTPase; Ch-1PTPase; DKFZp781C1038; EC-PTP; ECPTP; FLJ34328; MGC131968; MGC148170; NC-PTPCOM1; PCPTP1; protein tyrosine phosphatase Cr1PTPase; protein tyrosine phosphatase, receptor type, R; protein-tyrosine phosphatase NC-PTPCOM1; Protein-tyrosine phosphatase PCPTP1; PTP-SL; PTPBR7; PTPRQ; PTPRR; R-PTP-R; Receptor-type tyrosine-protein phosphatase R
Gene Symbols: PTPRR
Molecular weight: 73,834 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein