PTP-SL Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine
Chromosomal Location of human Ortholog: 12q15
Cellular Component:  cell junction; cytosol; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  protein binding; protein kinase binding; protein tyrosine phosphatase activity; transmembrane receptor protein tyrosine phosphatase activity
Biological Process:  ERBB2 signaling pathway; in utero embryonic development; negative regulation of epithelial cell migration; negative regulation of ERK1 and ERK2 cascade; peptidyl-tyrosine dephosphorylation; protein dephosphorylation; regulation of homophilic cell adhesion; signal transduction
Reference #:  Q15256 (UniProtKB)
Alt. Names/Synonyms: Ch-1 PTPase; Ch-1PTPase; DKFZp781C1038; EC-PTP; ECPTP; FLJ34328; MGC131968; MGC148170; NC-PTPCOM1; PCPTP1; protein tyrosine phosphatase Cr1PTPase; protein tyrosine phosphatase receptor type R; protein tyrosine phosphatase, receptor type, R; protein-tyrosine phosphatase NC-PTPCOM1; Protein-tyrosine phosphatase PCPTP1; PTP-SL; PTPBR7; PTPRQ; PTPRR; R-PTP-R; Receptor-type tyrosine-protein phosphatase R
Gene Symbols: PTPRR
Molecular weight: 73,834 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
Select Structure to View Below

PTP-SL

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein