PSMD4 Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. Displays a preferred selectivity for longer polyubiquitin chains. Belongs to the proteasome subunit S5A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Protease; Proteasome complex

Chromosomal Location of human Ortholog: 1q21.3

Cellular Component: cytosol; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle, base subcomplex

Molecular Function: identical protein binding; molecular adaptor activity; polyubiquitin modification-dependent protein binding; protein binding

Biological Process: proteasome-mediated ubiquitin-dependent protein catabolic process

Reference #: P55036 (UniProtKB)

Alt. Names/Synonyms: 26S protease subunit S5a; 26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit RPN10; 26S proteasome regulatory subunit S5A; AF; AF-1; angiocidin; Antisecretory factor 1; ASF; MCB1; multiubiquitin chain binding protein; Multiubiquitin chain-binding protein; proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; proteasome 26S non-ATPase subunit 4; proteasome 26S subunit, non-ATPase 4; PSMD4; pUB-R5; Rpn10; RPN10 homolog; S5A; S5a/antisecretory factor protein

Gene Symbols: PSMD4

Molecular weight: 40,737 Da

Basal Isoelectric point: 4.68 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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PSMD4

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