NHE3 Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Cellular Component: 
Reference #:  P26432 (UniProtKB)
Alt. Names/Synonyms: Na(+)/H(+) exchanger 3; Na/H exchanger 3; NHE-3; NHE3; SL9A3; SLC9A3; Sodium/hydrogen exchanger 3; Solute carrier family 9 member 3
Gene Symbols: NHE-3
Molecular weight: 92,749 Da
Basal Isoelectric point: 8.02  Predict pI for various phosphorylation states
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NHE3
Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene