Nogo Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely consecutive to their change in subcellular location, from the mitochondria to the endoplasmic reticulum, after binding and sequestration. Isoform 2 and isoform 3 inhibit BACE1 activity and amyloid precursor protein processing. 6 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Endoplasmic reticulum; Inhibitor; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2p16.1
Cellular Component:  cell junction; cell projection; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; endoplasmic reticulum tubular network membrane; integral component of endoplasmic reticulum membrane; neuronal cell body; nuclear envelope; plasma membrane; postsynaptic density
Molecular Function:  protein binding; ubiquitin protein ligase binding
Biological Process:  apoptotic process; axonal fasciculation; blastocyst formation; cardiac epithelial to mesenchymal transition; cellular sphingolipid homeostasis; cerebral cortex radial glia guided migration; endoplasmic reticulum tubular network formation; endoplasmic reticulum tubular network membrane organization; endoplasmic reticulum tubular network organization; negative regulation of axon extension; negative regulation of axonogenesis; negative regulation of cell growth; nuclear pore complex assembly; positive regulation of epithelial cell migration; positive regulation of ERBB3 signaling pathway; positive regulation of mammary gland epithelial cell proliferation; positive regulation of protein kinase B signaling; positive regulation of protein localization to endoplasmic reticulum; positive regulation of toll-like receptor 9 signaling pathway; protein localization to lysosome; protein stabilization; regulation of apoptotic process; regulation of branching morphogenesis of a nerve
Reference #:  Q9NQC3 (UniProtKB)
Alt. Names/Synonyms: ASY; Foocen; Human NogoA; KIAA0886; My043 protein; Nbla00271; Nbla10545; neurite growth inhibitor 220; Neurite outgrowth inhibitor; Neuroendocrine-specific protein; Neuroendocrine-specific protein C homolog; NI220/250; NOGO; Nogo protein; NOGO-A; Nogo-B; Nogo-C; NOGOC; NSP; NSP-CL; reticulon 4; reticulon 5; Reticulon-4; Reticulon-5; RTN-x; RTN4; RTN4-A; RTN4-B1; RTN4-B2; RTN4-C
Gene Symbols: RTN4
Molecular weight: 129,931 Da
Basal Isoelectric point: 4.43  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein