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neurogenin 2
a master regulatory transcription factor involved in neuronal differentiation. Controls the balance between progenitor maintenance and differentiation in the response to increasing cell cycle length during development. Its multi-site phosphorylation at CDK sites regulates the stability of its binding to promoters of downstream transcriptional targets, resulting in the regulation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Note: This description may include information from UniProtKB.
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| Protein type: Transcription factor |
| Chromosomal Location of Human Ortholog: 4q25 |
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Cellular Component:
nucleus
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Molecular Function:
DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; protein dimerization activity
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Biological Process:
neuron differentiation; positive regulation of DNA-binding transcription factor activity; regulation of transcription by RNA polymerase II
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Reference #:
Q9H2A3
(UniProtKB)
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Alt. Names/Synonyms: ATOH4; BHLHA8; Class A basic helix-loop-helix protein 8; Math4A; MGC46562; NEUROG2; neurogenin 2; Neurogenin-2; NGN-2; NGN2; Protein atonal homolog 4
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Gene Symbols: NEUROG2
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Molecular weight:
28,621 Da
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Basal Isoelectric point:
7.65
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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