neurogenin 2 a master regulatory transcription factor involved in neuronal differentiation. Controls the balance between progenitor maintenance and differentiation in the response to increasing cell cycle length during development. Its multi-site phosphorylation at CDK sites regulates the stability of its binding to promoters of downstream transcriptional targets, resulting in the regulation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 4q25
Cellular Component:  nucleus
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; E-box binding; protein dimerization activity
Biological Process:  neuron differentiation; positive regulation of DNA-binding transcription factor activity; regulation of transcription by RNA polymerase II
Reference #:  Q9H2A3 (UniProtKB)
Alt. Names/Synonyms: ATOH4; BHLHA8; Class A basic helix-loop-helix protein 8; Math4A; MGC46562; NEUROG2; neurogenin 2; Neurogenin-2; NGN-2; NGN2; Protein atonal homolog 4
Gene Symbols: NEUROG2
Molecular weight: 28,621 Da
Basal Isoelectric point: 7.65  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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neurogenin 2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene