KIF22 Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA. Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Expressed in bone, cartilage, joint capsule, ligament, skin, and primary cultured chondrocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component:  chromatin; cytosol; kinetochore; mitotic spindle; nuclear speck; nucleus
Molecular Function:  ATP binding; DNA binding; protein binding
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class II; DNA repair; metaphase plate congression; microtubule-based movement; mitotic cell cycle; mitotic metaphase plate congression; retrograde vesicle-mediated transport, Golgi to ER; sister chromatid cohesion
Disease: Spondyloepimetaphyseal Dysplasia With Joint Laxity Type 2
Reference #:  Q14807 (UniProtKB)
Alt. Names/Synonyms: KID; KIF22; kinesin family member 22; kinesin-like 4; Kinesin-like DNA-binding protein; Kinesin-like protein 4; Kinesin-like protein KIF22; KNSL4; OBP; OBP-1; OBP-2; origin of plasmid DNA replication-binding protein; oriP binding protein
Gene Symbols: KIF22
Molecular weight: 73,262 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
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KIF22

Protein Structure Not Found.


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