KCTD12 Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization. Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 13q22.3
Cellular Component:  cell junction; postsynaptic membrane; presynaptic membrane
Molecular Function:  identical protein binding
Biological Process:  protein homooligomerization
Reference #:  Q96CX2 (UniProtKB)
Alt. Names/Synonyms: BTB/POZ domain-containing protein KCTD12; C13orf2; FLJ33073; KCD12; KCTD12; KIAA1778; PFET1; Pfetin; potassium channel tetramerisation domain containing 12; potassium channel tetramerization domain containing 12; Predominantly fetal expressed T1 domain; testicular tissue protein Li 100
Gene Symbols: KCTD12
Molecular weight: 35,701 Da
Basal Isoelectric point: 5.51  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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KCTD12

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene