ITIH2 May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Belongs to the ITIH family. Plasma. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10p14
Cellular Component:  endoplasmic reticulum lumen; extracellular region
Molecular Function:  endopeptidase inhibitor activity; serine-type endopeptidase inhibitor activity
Biological Process:  cellular protein metabolic process; hyaluronan metabolic process; negative regulation of endopeptidase activity; post-translational protein modification
Reference #:  P19823 (UniProtKB)
Alt. Names/Synonyms: H2P; IGHEP2; inter-alpha (globulin) inhibitor H2; inter-alpha (globulin) inhibitor, H2 polypeptide; inter-alpha globulin inhibitor H2 polypeptide; Inter-alpha-inhibitor heavy chain 2; Inter-alpha-trypsin inhibitor complex component II; Inter-alpha-trypsin inhibitor heavy chain H2; ITI heavy chain H2; ITI-HC2; ITIH2; Serum-derived hyaluronan-associated protein; SHAP
Gene Symbols: ITIH2
Molecular weight: 106,463 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene