HINT1 Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Belongs to the HINT family. Widely expressed. Note: This description may include information from UniProtKB.

Protein type: Cytoskeletal; EC 3.-.-.-; Hydrolase

Chromosomal Location of human Ortholog: 5q23.3

Cellular Component: cytoplasm; cytoskeleton; cytosol; histone deacetylase complex; nucleoplasm; nucleus; plasma membrane

Molecular Function: adenosine 5'-monophosphoramidase activity; deSUMOylase activity; hydrolase activity; nucleotide binding; protein binding; protein kinase C binding

Biological Process: intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of calcium-mediated signaling; protein desumoylation; purine ribonucleotide catabolic process; regulation of DNA-templated transcription; signal transduction

Disease: Neuromyotonia And Axonal Neuropathy, Autosomal Recessive

Reference #: P49773 (UniProtKB)

Alt. Names/Synonyms: Adenosine 5'-monophosphoramidase; Adenosine 5'-monophosphoramidase HINT1; epididymis secretory sperm binding protein; FLJ30414; FLJ32340; HINT; HINT1; histidine triad nucleotide binding protein 1; Histidine triad nucleotide-binding protein 1; NMAN; PKCI-1; PKCI1; PRKCNH1; Protein kinase C inhibitor 1; Protein kinase C-interacting protein 1

Gene Symbols: HINT1

Molecular weight: 13,802 Da

Basal Isoelectric point: 6.43 Predict pI for various phosphorylation states

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HINT1

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