GRSF1 Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 4q13.3
Cellular Component:  cytoplasm; mitochondrial nucleoid; mitochondrion; ribonucleoprotein granule
Molecular Function:  mRNA binding; protein binding
Biological Process:  anterior/posterior pattern specification; morphogenesis of embryonic epithelium; mRNA polyadenylation; tRNA processing
Reference #:  Q12849 (UniProtKB)
Alt. Names/Synonyms: FLJ13125; G-rich RNA sequence binding factor 1; G-rich sequence factor 1; GRSF-1; GRSF1
Gene Symbols: GRSF1
Molecular weight: 53,126 Da
Basal Isoelectric point: 5.83  Predict pI for various phosphorylation states
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GRSF1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB