AP-2 alpha Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Belongs to the AP-2 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 13 A3.3|13 20.01 cM
Cellular Component:  clathrin-coated pit; nucleoplasm; nucleus; transcription regulator complex
Molecular Function:  chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; identical protein binding; nuclear receptor corepressor activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coactivator activity; transcription corepressor activity
Biological Process:  anatomical structure development; anterior neuropore closure; basement membrane organization; bone morphogenesis; cell population proliferation; cellular response to iron ion; cornea development in camera-type eye; embryonic body morphogenesis; embryonic camera-type eye morphogenesis; embryonic cranial skeleton morphogenesis; embryonic forelimb morphogenesis; embryonic pattern specification; epidermal growth factor receptor signaling pathway; epidermis morphogenesis; eyelid development in camera-type eye; face morphogenesis; fibroblast migration; forebrain neuron development; forelimb morphogenesis; inner ear morphogenesis; keratinocyte development; kidney development; lens induction in camera-type eye; lens morphogenesis in camera-type eye; metanephric nephron development; negative regulation of apoptotic process; negative regulation of cell population proliferation; negative regulation of DNA-templated transcription; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of neuron apoptotic process; negative regulation of reactive oxygen species metabolic process; negative regulation of transcription by competitive promoter binding; negative regulation of transcription by RNA polymerase II; nervous system development; neural crest cell development; neural tube closure; neuron apoptotic process; oculomotor nerve formation; optic cup structural organization; optic vesicle morphogenesis; outflow tract morphogenesis; positive regulation of bone mineralization; positive regulation of DNA-templated transcription; positive regulation of fibroblast migration; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of tooth mineralization; positive regulation of transcription by RNA polymerase II; regulation of cell differentiation; regulation of cell population proliferation; regulation of DNA-templated transcription; regulation of neuron differentiation; regulation of transcription by RNA polymerase II; response to lipopolysaccharide; roof of mouth development; sensory organ development; sensory perception of sound; skeletal system morphogenesis; skin development; sympathetic nervous system development; transcription by RNA polymerase II; trigeminal nerve development
Reference #:  P34056 (UniProtKB)
Alt. Names/Synonyms: activating enhancer-binding protein 2 alpha; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; Ap-2 (a); AP-2 alpha; AP-2 transcription factor; Ap2; AP2-alpha; AP2A; AP2alpha; Ap2tf; Tcfa; Tcfap2a; Tfap2a; transcription factor AP-2 alpha; transcription factor AP-2, alpha; Transcription factor AP-2-alpha
Gene Symbols: Tfap2a
Molecular weight: 47,971 Da
Basal Isoelectric point: 8.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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AP-2 alpha

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene