AP-2 alpha Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Belongs to the AP-2 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 6p24.3
Cellular Component:  centrosome; cytosol; Golgi apparatus; intracellular membrane-bounded organelle; nucleoplasm; nucleus
Molecular Function:  chromatin binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; protein binding; protein dimerization activity; protein homodimerization activity; proximal promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator activity; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding
Biological Process:  bone morphogenesis; cellular response to iron ion; embryonic cranial skeleton morphogenesis; embryonic forelimb morphogenesis; eyelid development in camera-type eye; inner ear morphogenesis; kidney development; negative regulation of apoptotic process; negative regulation of cell proliferation; negative regulation of reactive oxygen species metabolic process; negative regulation of transcription by competitive promoter binding; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; oculomotor nerve formation; optic cup structural organization; optic vesicle morphogenesis; positive regulation of bone mineralization; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of tooth mineralization; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of cell differentiation; regulation of transcription by RNA polymerase II; retina layer formation; roof of mouth development; sensory perception of sound; trigeminal nerve development
Disease: Branchiooculofacial Syndrome
Reference #:  P05549 (UniProtKB)
Alt. Names/Synonyms: Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; AP-2 transcription factor; AP-2alpha; AP2-alpha; AP2A; AP2TF; BOFS; FLJ51761; TFAP2; TFAP2A; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Transcription factor AP-2-alpha
Gene Symbols: TFAP2A
Molecular weight: 48,062 Da
Basal Isoelectric point: 8.1  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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AP-2 alpha

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein