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RRM2
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 12 A1.3|12 8.5 cM |
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Cellular Component:
cytoplasm; cytosol; nuclear envelope; nucleus; ribonucleoside-diphosphate reductase complex
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Molecular Function:
ferric iron binding; identical protein binding; metal ion binding; oxidoreductase activity; protein binding; protein homodimerization activity; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
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Biological Process:
2'-deoxyribonucleotide biosynthetic process; blastocyst development; deoxyribonucleotide biosynthetic process; deoxyribonucleotide metabolic process; positive regulation of G1/S transition of mitotic cell cycle; protein heterotetramerization; ribonucleoside diphosphate metabolic process
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Reference #:
P11157
(UniProtKB)
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Alt. Names/Synonyms: AA407299; MGC113712; R2; ribonucleoside-diphosphate reductase M2 chain; Ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase M2; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; RIR2; Rrm2
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Gene Symbols: Rrm2
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Molecular weight:
45,096 Da
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Basal Isoelectric point:
5.33
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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