RRM2 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling. Belongs to the ribonucleoside diphosphate reductase small chain family. Note: This description may include information from UniProtKB.
Protein type: EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase
Chromosomal Location of Human Ortholog: 2p25.1
Cellular Component:  cytosol; ribonucleoside-diphosphate reductase complex
Molecular Function:  ferric iron binding; protein binding; protein homodimerization activity; ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Process:  deoxyribonucleotide biosynthetic process; DNA replication; negative regulation of G0 to G1 transition; nucleobase-containing small molecule interconversion; oxidation-reduction process; protein heterotetramerization; regulation of transcription involved in G1/S transition of mitotic cell cycle
Reference #:  P31350 (UniProtKB)
Alt. Names/Synonyms: R2; Ribonucleoside-diphosphate reductase subunit M2; ribonucleotide reductase M2; ribonucleotide reductase M2 polypeptide; Ribonucleotide reductase small chain; Ribonucleotide reductase small subunit; RIR2; RR2; RR2M; RRM2
Gene Symbols: RRM2
Molecular weight: 44,878 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
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RRM2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein