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RRAD
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. Belongs to the small GTPase superfamily. RGK family. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans. Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, monomeric; G protein, monomeric, RGK |
| Chromosomal Location of mouse Ortholog: 8|8 D3 |
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Cellular Component:
membrane; plasma membrane
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Molecular Function:
calcium channel regulator activity; calmodulin binding; GTP binding; GTPase activity; nucleotide binding; protein binding
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Biological Process:
negative regulation of cell growth; negative regulation of high voltage-gated calcium channel activity; regulation of high voltage-gated calcium channel activity
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Reference #:
O88667
(UniProtKB)
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Alt. Names/Synonyms: GTP-binding protein RAD; Rad; Ras-like GTP-binding protein rad; Ras-related associated with diabetes; REM; REM3; Rrad
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Gene Symbols: Rrad
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Molecular weight:
33,279 Da
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Basal Isoelectric point:
9.25
Predict pI for various phosphorylation states
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