RRAD May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. Belongs to the small GTPase superfamily. RGK family. Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, RGK
Chromosomal Location of human Ortholog: 16q22.1
Cellular Component:  cytosol; plasma membrane
Molecular Function:  calcium channel regulator activity; calmodulin binding; GTP binding; GTPase activity; protein binding
Biological Process:  negative regulation of high voltage-gated calcium channel activity; small GTPase mediated signal transduction
Reference #:  P55042 (UniProtKB)
Alt. Names/Synonyms: GTP-binding protein RAD; RAD; RAD1; RAS (RAD and GEM) like GTP binding 3; Ras associated with diabetes; Ras-related associated with diabetes; REM3; RRAD; RRAD, Ras related glycolysis inhibitor and calcium channel regulator; RRAD, Ras related glycolysis inihibitor and calcium channel regulator
Gene Symbols: RRAD
Molecular weight: 33,245 Da
Basal Isoelectric point: 9.06  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein