RAB5A The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3. Belongs to the small GTPase superfamily. Rab family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 3p24.3
Cellular Component:  actin cytoskeleton; axon; axon terminus; clathrin-coated endocytic vesicle membrane; cytoplasm; cytoplasmic side of early endosome membrane; cytosol; dendrite; early endosome; early endosome membrane; early phagosome; endocytic vesicle; endomembrane system; endosome; endosome membrane; intracellular membrane-bounded organelle; melanosome; membrane raft; neuronal cell body; nucleoplasm; phagocytic vesicle; phagocytic vesicle membrane; plasma membrane; postsynaptic early endosome; ruffle; somatodendritic compartment; synaptic vesicle; synaptic vesicle membrane; terminal bouton
Molecular Function:  G protein activity; GDP binding; GTP binding; GTPase activity; protein binding
Biological Process:  amyloid-beta clearance by transcytosis; early endosome to late endosome transport; endocytosis; intracellular protein transport; modulation by host of viral process; phagocytosis; positive regulation of exocytosis; receptor internalization involved in canonical Wnt signaling pathway; regulation of autophagosome assembly; regulation of endocytosis; regulation of endosome size; regulation of filopodium assembly; regulation of long-term neuronal synaptic plasticity; regulation of synaptic vesicle exocytosis; synaptic vesicle recycling
Reference #:  P20339 (UniProtKB)
Alt. Names/Synonyms: RAB5; RAB5A; RAB5A, member RAS oncogene family; RAS-associated protein RAB5A; Ras-related protein Rab-5A
Gene Symbols: RAB5A
Molecular weight: 23,659 Da
Basal Isoelectric point: 8.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB