RAB5A The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3. Belongs to the small GTPase superfamily. Rab family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p24.3
Cellular Component:  actin cytoskeleton; axon; axon terminus; clathrin-coated vesicle membrane; cytoplasm; cytoplasmic side of early endosome membrane; cytosol; dendrite; early endosome; early endosome membrane; early phagosome; endosome; endosome membrane; melanosome; membrane raft; neuronal cell body; phagocytic vesicle; phagocytic vesicle membrane; ruffle; somatodendritic compartment; synaptic vesicle; terminal bouton
Molecular Function:  GDP binding; GTP binding; GTPase activity; protein binding
Biological Process:  amyloid-beta clearance by transcytosis; blood coagulation; early endosome to late endosome transport; endocytosis; membrane organization; phagocytosis; phosphatidylinositol biosynthetic process; positive regulation of exocytosis; post-translational protein modification; receptor internalization involved in canonical Wnt signaling pathway; regulation of autophagosome assembly; regulation of endosome size; regulation of filopodium assembly; regulation of synaptic vesicle exocytosis; synaptic vesicle recycling; viral RNA genome replication
Reference #:  P20339 (UniProtKB)
Alt. Names/Synonyms: RAB5; RAB5A; RAB5A, member RAS oncogene family; RAS-associated protein RAB5A; Ras-related protein Rab-5A
Gene Symbols: RAB5A
Molecular weight: 23,659 Da
Basal Isoelectric point: 8.32  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB