PPP2R5D The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B56 family. Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 17 22.9 cM|17 C
Cellular Component:  cytosol; nucleus; protein phosphatase type 2A complex
Molecular Function:  phosphoprotein phosphatase activity; protein binding; protein phosphatase activator activity
Biological Process:  cellular response to growth factor stimulus; negative regulation of peptidyl-threonine phosphorylation; positive regulation of neuron projection development; positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of protein dephosphorylation; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; regulation of protein autophosphorylation; regulation of protein phosphorylation
Reference #:  Q7TNL5 (UniProtKB)
Alt. Names/Synonyms: B'delta; delta isoform of regulatory subunit B56, protein phosphatase 2A; Ppp2r5d; protein phosphatase 2, regulatory subunit B (B56), delta isoform; Protein phosphatase 2, regulatory subunit B (B56), delta isoform, isoform CRA_a; Protein phosphatase 2A B56 delta subunit; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; TEG-271; testis expressed gene 271; Tex271
Gene Symbols: Ppp2r5d
Molecular weight: 69,123 Da
Basal Isoelectric point: 7.99  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene