|
PPP2R5D
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGOL1. By retinoic acid; in neuroblastoma cell lines. Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. Belongs to the phosphatase 2A regulatory subunit B56 family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
|
| Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit |
| Chromosomal Location of Human Ortholog: 17 22.9 cM|17 C |
|
Cellular Component:
cytosol; nucleus; protein phosphatase type 2A complex
|
|
Molecular Function:
phosphoprotein phosphatase activity; protein binding; protein phosphatase activator activity
|
|
Biological Process:
cellular response to growth factor stimulus; negative regulation of peptidyl-threonine phosphorylation; positive regulation of neuron projection development; positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of protein dephosphorylation; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; regulation of protein autophosphorylation; regulation of protein phosphorylation
|
|
Reference #:
Q7TNL5
(UniProtKB)
|
|
Alt. Names/Synonyms: B'delta; delta isoform of regulatory subunit B56, protein phosphatase 2A; Ppp2r5d; protein phosphatase 2, regulatory subunit B (B56), delta isoform; Protein phosphatase 2, regulatory subunit B (B56), delta isoform, isoform CRA_a; Protein phosphatase 2A B56 delta subunit; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; TEG-271; testis expressed gene 271; Tex271
|
|
Gene Symbols: Ppp2r5d
|
|
Molecular weight:
69,123 Da
|
|
Basal Isoelectric point:
7.99
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
