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PPP2R5D
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B56 family. Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit |
| Chromosomal Location of Human Ortholog: 17 22.9 cM|17 C |
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Cellular Component:
cytosol; nucleus; protein phosphatase type 2A complex
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Molecular Function:
phosphoprotein phosphatase activity; protein binding; protein phosphatase activator activity
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Biological Process:
cellular response to growth factor stimulus; negative regulation of peptidyl-threonine phosphorylation; positive regulation of neuron projection development; positive regulation of neurotrophin TRK receptor signaling pathway; positive regulation of protein dephosphorylation; positive regulation of transcription by RNA polymerase II; protein dephosphorylation; regulation of protein autophosphorylation; regulation of protein phosphorylation
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Reference #:
Q7TNL5
(UniProtKB)
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Alt. Names/Synonyms: B'delta; delta isoform of regulatory subunit B56, protein phosphatase 2A; Ppp2r5d; protein phosphatase 2, regulatory subunit B (B56), delta isoform; Protein phosphatase 2, regulatory subunit B (B56), delta isoform, isoform CRA_a; Protein phosphatase 2A B56 delta subunit; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; TEG-271; testis expressed gene 271; Tex271
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Gene Symbols: Ppp2r5d
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Molecular weight:
69,123 Da
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Basal Isoelectric point:
7.99
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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