PPP2R5D
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B56 family. Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit |
Chromosomal Location of human Ortholog: 6p21.1 |
Cellular Component:
cytosol; nucleoplasm; nucleus; protein phosphatase type 2A complex
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Molecular Function:
phosphoprotein phosphatase activity; protein binding; protein phosphatase activator activity; protein phosphatase regulator activity
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Biological Process:
negative regulation of peptidyl-threonine phosphorylation; nervous system development; positive regulation of protein dephosphorylation; protein dephosphorylation; signal transduction
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Disease: Mental Retardation, Autosomal Dominant 35
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Reference #:
Q14738
(UniProtKB)
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Alt. Names/Synonyms: 2A5D; B56D; B56delta; MGC2134; MGC8949; MRD35; PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; PPP2R5D; protein phosphatase 2 regulatory subunit B'delta; protein phosphatase 2, regulatory subunit B (B56), delta isoform; protein phosphatase 2, regulatory subunit B', delta; protein phosphatase 2, regulatory subunit B', delta isoform; Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
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Gene Symbols: PPP2R5D
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Molecular weight:
69,992 Da
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Basal Isoelectric point:
8.24
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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