PPP2R5D The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. Belongs to the phosphatase 2A regulatory subunit B56 family. Isoform Delta-2 is widely expressed. Isoform Delta-1 is highly expressed in brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit
Chromosomal Location of human Ortholog: 6p21.1
Cellular Component:  cytosol; nucleoplasm; nucleus; protein phosphatase type 2A complex
Molecular Function:  phosphoprotein phosphatase activity; protein binding; protein phosphatase activator activity; protein phosphatase regulator activity
Biological Process:  negative regulation of peptidyl-threonine phosphorylation; nervous system development; positive regulation of protein dephosphorylation; protein dephosphorylation; signal transduction
Disease: Mental Retardation, Autosomal Dominant 35
Reference #:  Q14738 (UniProtKB)
Alt. Names/Synonyms: 2A5D; B56D; B56delta; MGC2134; MGC8949; MRD35; PP2A B subunit isoform B'-delta; PP2A B subunit isoform B56-delta; PP2A B subunit isoform PR61-delta; PP2A B subunit isoform R5-delta; PP2A, B subunit, B' delta isoform; PP2A, B subunit, B56 delta isoform; PP2A, B subunit, PR61 delta isoform; PP2A, B subunit, R5 delta isoform; PPP2R5D; protein phosphatase 2 regulatory subunit B'delta; protein phosphatase 2, regulatory subunit B (B56), delta isoform; protein phosphatase 2, regulatory subunit B', delta; protein phosphatase 2, regulatory subunit B', delta isoform; Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform; Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
Gene Symbols: PPP2R5D
Molecular weight: 69,992 Da
Basal Isoelectric point: 8.24  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PPP2R5D

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein