p67phox NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production). Interacts with SYTL1 and RAC1. Interacts with NCF4. May interact with NOXO1. Belongs to the NCF2/NOXA1 family. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 1q25.3
Cellular Component:  acrosomal vesicle; cytosol; NADPH oxidase complex; nucleolus; phagolysosome
Molecular Function:  electron transfer activity; protein binding; protein C-terminus binding; Rac GTPase binding; superoxide-generating NADPH oxidase activator activity; superoxide-generating NADPH oxidase activity
Biological Process:  antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; cellular defense response; cellular response to oxidative stress; electron transport chain; innate immune response; phagocytosis; positive regulation of catalytic activity; respiratory burst; superoxide anion generation; superoxide metabolic process; vascular endothelial growth factor receptor signaling pathway
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type Ii
Reference #:  P19878 (UniProtKB)
Alt. Names/Synonyms: 67 kDa neutrophil oxidase factor; chronic granulomatous disease, autosomal 2; FLJ93058; NADPH oxidase activator 2; NCF-2; NCF2; Neutrophil cytosol factor 2; neutrophil cytosolic factor 2; neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2); Neutrophil NADPH oxidase factor 2; NOXA2; p67-phox; P67PHOX
Gene Symbols: NCF2
Molecular weight: 59,762 Da
Basal Isoelectric point: 5.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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