Myf-5 Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of mouse Ortholog: 10 D1|10 55.95 cM
Cellular Component:  nucleoplasm; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein dimerization activity; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding
Biological Process:  camera-type eye development; cartilage condensation; cell differentiation; embryonic skeletal system morphogenesis; extracellular matrix organization; multicellular organism development; muscle organ development; muscle organ morphogenesis; muscle tissue morphogenesis; ossification; positive regulation of myoblast differentiation; positive regulation of myoblast fusion; positive regulation of skeletal muscle fiber development; positive regulation of transcription by RNA polymerase II; regulation of cell-matrix adhesion; regulation of transcription, DNA-templated; skeletal muscle cell differentiation; skeletal muscle tissue development; somitogenesis
Reference #:  P24699 (UniProtKB)
Alt. Names/Synonyms: B130010J22Rik; bHLHc; bHLHc2; Myf-5; Myf5; Myogenic factor 5; myogenic regulatory factor MYF-5
Gene Symbols: Myf5
Molecular weight: 28,229 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene