Myf-5 Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 12q21.31
Cellular Component:  nucleoplasm; RNA polymerase II transcription factor complex
Molecular Function:  DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; protein heterodimerization activity
Biological Process:  camera-type eye development; cartilage condensation; embryonic skeletal system morphogenesis; extracellular matrix organization; muscle cell fate commitment; muscle organ development; muscle tissue morphogenesis; ossification; positive regulation of muscle cell differentiation; regulation of cell-matrix adhesion; regulation of transcription by RNA polymerase II; skeletal muscle tissue development; somitogenesis
Disease: Ophthalmoplegia, External, With Rib And Vertebral Anomalies
Reference #:  P13349 (UniProtKB)
Alt. Names/Synonyms: BHLHC2; Class C basic helix-loop-helix protein 2; Myf-5; MYF5; Myogenic factor 5
Gene Symbols: MYF5
Molecular weight: 28,296 Da
Basal Isoelectric point: 5.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene