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KLF1
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation. Belongs to the krueppel C2H2-type zinc-finger protein family. Expression restricted to adult bone marrow and fetal liver. Not expressed in myeloid nor lymphoid cell lines. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of Human Ortholog: 8 41.3 cM|8 C3 |
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Cellular Component:
nuclear chromatin; nucleoplasm; nucleus
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Molecular Function:
activating transcription factor binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; nucleic acid binding; protein binding; protein domain specific binding; proximal promoter sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription regulatory region DNA binding
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Biological Process:
chromatin remodeling; embryonic hemopoiesis; erythrocyte development; erythrocyte differentiation; erythrocyte maturation; in utero embryonic development; liver development; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated
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Reference #:
P46099
(UniProtKB)
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Alt. Names/Synonyms: EKLF; Elkf; Erythroid krueppel-like transcription factor; erythroid transcription factor; Klf1; Krueppel-like factor 1; Kruppel-like factor 1 (erythroid)
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Gene Symbols: Klf1
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Molecular weight:
37,757 Da
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Basal Isoelectric point:
6.94
Predict pI for various phosphorylation states
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