GPLD1 This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane. Belongs to the GPLD1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Phospholipase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 13 A3.1|13 10.79 cM
Cellular Component:  cytoplasm; extracellular matrix; extracellular region; extracellular space; high-density lipoprotein particle; intracellular membrane-bounded organelle
Molecular Function:  glycosylphosphatidylinositol phospholipase D activity; hydrolase activity; phospholipase D activity; protein binding; sodium channel regulator activity
Biological Process:  cell migration involved in sprouting angiogenesis; cellular response to calcium ion; cellular response to cholesterol; cellular response to drug; cellular response to inorganic substance; cellular response to insulin stimulus; cellular response to iron(II) ion; cellular response to pH; cellular response to triglyceride; chondrocyte differentiation; complement receptor mediated signaling pathway; GPI anchor release; insulin receptor signaling pathway; negative regulation of cell proliferation; negative regulation of triglyceride catabolic process; ossification; positive regulation of apoptotic process; positive regulation of cytolysis; positive regulation of endothelial cell migration; positive regulation of glucose metabolic process; positive regulation of high-density lipoprotein particle clearance; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of membrane protein ectodomain proteolysis; positive regulation of secretion; positive regulation of triglyceride biosynthetic process; regulation of cellular response to insulin stimulus; response to glucose; transepithelial transport
Reference #:  O70362 (UniProtKB)
Alt. Names/Synonyms: 6330541J12Rik; AW546131; Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; glycosylphosphatidylinositol specific phospholipase D1; GPI-PLD; GPI-specific phospholipase D; Gpld1; OTTMUSP00000000654; PHLD; Phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD
Gene Symbols: Gpld1
Molecular weight: 93,255 Da
Basal Isoelectric point: 6.65  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene